It could be one of several safety or battery-related reasons:

Your Vuse ePod 2+ is designed to automatically stop producing vapour if activated for more than five seconds.

It will also stop producing vapour and automatically lock if you vape for a total of more than 40 seconds in a 60 second period. If you vape in this period the LED will flash red and no vapour will be produced. Wait 30 seconds and then unlock to vape again.

Your Vuse ePod 2+ device is designed to automatically stop prodcuing vapour if a short circuit is detected. The LED will flash red three times, try using a different pod. If the problem persists contact cosumer care.

If you've locked your Vuse ePod 2+ (either via the button or the MyVuseApp), the LED will light red and vibrate to remind you to unlock the device, no vapour will be produced. Simply unlock by pressing the button three times in 2 seconds or unlock from the MyVuseApp (when phone is in range).

Your Vuse ePod 2+ needs charging.

You need to change your Vuse ePod pod.

Dirt might be blocking the connection between the device and the pod. Try cleaning it with a dry cloth.